DHCR24

Across TCGA patient cohorts, DHCR24 protein abundance is significantly associated with the RNA expression of many other genes, with 11,472 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible DHCR24-associated genes across cancer lineages are RNF180, DHCR24-DT, and GASK1A. Each is linked with DHCR24 in more than 8 cancer types. Because this analysis shows association rather than direction, both DHCR24-to-partner and partner-to-DHCR24 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DHCR24 versus RNF180 in GBM, with a Pearson correlation of -0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHCR24→partner) and Y-score (partner→DHCR24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RNF180 →	-0.949	-0.514	<.001	<.001	3	9
OV	DHCR24-DT →	+0.569	+0.812	.008	.004	3	7
HNSC	GASK1A →	-0.721	-0.584	.001	.002	3	6
HNSC	ANK2 →	-0.785	-0.576	<.001	<.001	3	5
HNSC	GBGT1 →	-1.032	-0.964	<.001	<.001	3	5
HNSC	KCNA6 →	-0.437	-0.396	.003	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,472 associations by consensus.

DHCR24 vs RNF180 — GBM

Explore this scatter interactively →