DHCR24

Across TCGA pan-cancer cohorts, DHCR24 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of DHCR24’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where DHCR24 RNA is repressed in tumor relative to normal tissue. In most cancer types DHCR24 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

LUAD, BLCA, and LUSC are the cancer types where DHCR24 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DHCR24 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	−1.766	<.001	11	view →
BLCA	Male	III,IV	+3.632	<.001	8	view →
LUSC	Male	II,III,IV	−1.534	<.001	6	view →
BRCA	All	III,IV	+1.117	<.001	6	view →
KIRC	Male	II,III,IV	−0.775	.003	6	view →
KICH	All	All	−1.284	<.001	5	view →
LIHC	Male	All	+0.690	<.001	4	view →
PRAD	All	All	+0.944	<.001	2	view →
THCA	All	All	−0.345	.018	2	view →
KIRP	Male	II,III,IV	+0.771	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

DHCR24–LUAD

Open the LUAD breakdown →