DHCR24

Across TCGA pan-cancer cohorts, DHCR24 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated DHCR24 data layer compared with 6 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher DHCR24 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DHCR24 expression acts as an unfavorable survival marker, although some lineages such as LUAD and READ show a favorable association.

BLCA, UCEC, and KICH are the cancer types where DHCR24 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Quartile	II,III,IV	0.276	0.417	.011	48	view →
UCEC	DFS	Median	All	0.780	0.892	<.001	44	view →
KICH	DFS	Tertile	All	0.740	1.000	.007	34	view →
UVM	DFS	Tertile	III,IV	0.186	1.000	.002	34	view →
LUAD	DFS	Median	All	0.435	0.264	.002	30	view →
READ	DFS	Tertile	All	0.869	0.611	.002	25	view →
SARC	DFS	Quartile	All	0.173	0.591	<.001	21	view →
THYM	OS	Median	All	1.000	0.657	.006	16	view →
PAAD	DFS	Tertile	All	0.239	0.515	<.001	15	view →
CHOL	DFS	Median	III,IV	0.127	0.647	.006	12	view →
ACC	DFS	Median	III,IV	0.553	0.140	.012	8	view →
MESO	DFS	Quartile	III,IV	0.124	0.596	.010	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

DHCR24–BLCA (DFS)

Open the BLCA breakdown →