DHCR24

Across TCGA patient cohorts, DHCR24 mutation is significantly associated with the RNA expression of many other genes, with 2,441 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHCR24-associated genes across cancer lineages are THOC3-AS1, MIR920, and MIR183. Each is linked with DHCR24 in more than 1 cancer types. Because this analysis shows association rather than direction, both DHCR24-to-partner and partner-to-DHCR24 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, THOC3-AS1 grouped by DHCR24-low versus DHCR24-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHCR24→partner) and Y-score (partner→DHCR24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	THOC3-AS1 →	+0.183	+1.595	.004	.005	3	2
CESC	MIR920 →	+0.429	+4.539	<.001	.008	3	2
PRAD	MIR183 →	+0.288	+7.939	<.001	.008	3	1
PRAD	MIR501 →	+0.358	+7.939	<.001	.008	3	1
UCEC	CCL5 →	+0.837	+2.338	.005	.003	3	1
UCEC	LINC02427 →	-0.204	-2.074	.008	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,441 associations by consensus.

THOC3-AS1 by DHCR24 expression — UCEC

Explore this box plot interactively →