DHCR24

Across TCGA patient cohorts, DHCR24 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHCR24-associated genes across cancer lineages are ATM, 14-3-3_beta, and eEF2. Each is linked with DHCR24 in more than 1 cancer types. Because this analysis shows association rather than direction, both DHCR24-to-partner and partner-to-DHCR24 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by DHCR24-low versus DHCR24-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHCR24→partner) and Y-score (partner→DHCR24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.462	-2.000	.003	.003	3	2
UCEC	14-3-3_beta →	-0.071	-1.847	.045	.049	3	1
UCEC	eEF2 →	+0.396	+2.700	.001	.005	3	1
UCEC	EGFR_pY1068 →	-0.309	-2.502	<.001	.001	3	1
UCEC	eIF4E →	+0.265	+3.713	<.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.180	-2.222	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

ATM by DHCR24 expression — UCEC

Explore this box plot interactively →