DGLUCY

Across TCGA cell cohorts, DGLUCY mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DGLUCY-associated genes across cancer lineages are CST9, SERPINA7, and TAFA1. Each is linked with DGLUCY in more than 1 cancer types. Because this analysis shows association rather than direction, both DGLUCY-to-partner and partner-to-DGLUCY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CST9 grouped by DGLUCY-low versus DGLUCY-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DGLUCY→partner) and Y-score (partner→DGLUCY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CST9 →	+0.046	+4.981	<.001	.008	3	1
LUNG_NSCLC_LUAD	SERPINA7 →	+0.013	+5.228	<.001	.005	3	1
LARGE_INTESTINE	TAFA1 →	+0.274	+3.688	<.001	.002	3	1
LARGE_INTESTINE	TAS2R60 →	+0.017	+3.347	.005	.005	3	1
LARGE_INTESTINE	CENPVL3 →	+0.273	+4.242	<.001	.001	3	1
BREAST	OR4E2 →	+0.025	+5.169	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

CST9 by DGLUCY expression — CNS

Explore this box plot interactively →