DGLUCY

Across TCGA pan-cancer cohorts, DGLUCY RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of DGLUCY’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where DGLUCY RNA is repressed in tumor relative to normal tissue. In most cancer types DGLUCY is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and LUAD are the cancer types where DGLUCY tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DGLUCY RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.799	<.001	12	view →
THCA	Male	III,IV	−1.294	<.001	11	view →
LUAD	Female	III,IV	−0.991	<.001	11	view →
COAD	All	III,IV	−0.804	<.001	11	view →
HNSC	Male	All	−0.837	<.001	9	view →
BLCA	Male	III,IV	−1.764	<.001	8	view →
LUSC	Male	II,III,IV	−0.826	<.001	8	view →
BRCA	All	III,IV	−0.678	<.001	6	view →
UCEC	All	All	−0.679	.003	4	view →
READ	All	All	−0.964	<.001	3	view →
STAD	Female	All	−0.802	.003	3	view →
KICH	Female	All	+0.633	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

DGLUCY–KIRC

Open the KIRC breakdown →