DGKQ

Across TCGA patient cohorts, DGKQ mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DGKQ-associated genes across cancer lineages are GAPDH, ERK2, and mTOR_pS2448. Each is linked with DGKQ in more than 1 cancer types. Because this analysis shows association rather than direction, both DGKQ-to-partner and partner-to-DGKQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by DGKQ-low versus DGKQ-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DGKQ→partner) and Y-score (partner→DGKQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.608	+2.700	.009	.006	3	2
UCEC	ERK2 →	+0.247	+3.459	.003	.005	3	1
UCEC	mTOR_pS2448 →	-0.143	-2.302	.028	.034	3	1
UCEC	N-Ras →	-0.106	-2.102	.042	.019	3	1
UCEC	PCNA →	+0.194	+2.115	.040	.019	3	1
UCEC	PDK1_pS241 →	+0.174	+1.598	.019	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

GAPDH by DGKQ expression — UCEC

Explore this box plot interactively →