DGKQ

Across TCGA cell cohorts, DGKQ mutation is significantly associated with the RNA expression of many other genes, with 460 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DGKQ-associated genes across cancer lineages are ALDH6A1, OR56A5, and OR8B4. Each is linked with DGKQ in more than 1 cancer types. Because this analysis shows association rather than direction, both DGKQ-to-partner and partner-to-DGKQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ALDH6A1 grouped by DGKQ-low versus DGKQ-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DGKQ→partner) and Y-score (partner→DGKQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ALDH6A1 →	+0.892	+3.212	.004	.006	3	2
LUNG_NSCLC_LUAD	OR56A5 →	+0.111	+4.887	<.001	.009	3	2
LUNG_NSCLC_LUAD	OR8B4 →	+0.045	+4.887	<.001	.009	3	2
BLOOD_Leukemia	NAPG →	+0.569	+3.351	<.001	.003	3	2
BLOOD_Leukemia	C11orf65 →	+0.378	+3.351	<.001	.003	3	2
BLOOD_Leukemia	WNT8A →	+0.475	+3.115	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 460 associations by consensus.

ALDH6A1 by DGKQ expression — LARGE_INTESTINE

Explore this box plot interactively →