DGKI

Across TCGA patient cohorts, DGKI mutation is significantly associated with the RNA expression of many other genes, with 6,975 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DGKI-associated genes across cancer lineages are KNL1, DEPDC1, and RCC1. Each is linked with DGKI in more than 5 cancer types. Because this analysis shows association rather than direction, both DGKI-to-partner and partner-to-DGKI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KNL1 grouped by DGKI-low versus DGKI-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DGKI→partner) and Y-score (partner→DGKI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KNL1 →	+0.699	+1.669	<.001	<.001	3	6
LUAD	DEPDC1 →	+0.758	+2.459	.001	<.001	3	5
UCEC	RCC1 →	+0.512	+1.680	<.001	<.001	3	5
UCEC	GLO1 →	+0.447	+1.376	<.001	.001	3	5
UCEC	PAICS →	+0.615	+3.069	<.001	<.001	3	5
LUAD	SGO1 →	+0.713	+2.938	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,975 associations by consensus.

KNL1 by DGKI expression — UCEC

Explore this box plot interactively →