DGKI

Across TCGA pan-cancer cohorts, DGKI RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of DGKI’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where DGKI RNA is repressed in tumor relative to normal tissue. In most cancer types DGKI is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.

THCA, KIRP, and HNSC are the cancer types where DGKI tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DGKI RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−4.215	<.001	11	view →
KIRP	Male	All	−0.724	<.001	11	view →
HNSC	All	III,IV	+0.522	<.001	10	view →
LUAD	All	III,IV	+0.341	<.001	9	view →
KIRC	All	All	+0.410	<.001	8	view →
LIHC	All	All	+0.158	<.001	8	view →
BRCA	All	All	−0.390	<.001	6	view →
KICH	Male	All	+1.670	<.001	5	view →
LUSC	Male	II,III,IV	+0.468	<.001	5	view →
UCEC	All	All	−0.336	.011	2	view →
CHOL	All	All	+0.335	.010	2	view →
READ	Male	All	+0.273	.026	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

DGKI–THCA

Open the THCA breakdown →