DGKG

Across TCGA patient cohorts, DGKG mutation is significantly associated with the RNA expression of many other genes, with 2,577 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DGKG-associated genes across cancer lineages are GUF1, POLRMT, and INTS6L. Each is linked with DGKG in more than 2 cancer types. Because this analysis shows association rather than direction, both DGKG-to-partner and partner-to-DGKG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GUF1 grouped by DGKG-low versus DGKG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DGKG→partner) and Y-score (partner→DGKG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GUF1 →	+0.484	+1.747	<.001	<.001	3	3
SKCM	POLRMT →	+0.341	+1.504	.003	.007	3	3
SKCM	INTS6L →	-0.572	-3.769	.006	<.001	3	3
UCEC	TANGO2 →	+0.330	+1.546	<.001	.001	3	3
UCEC	KMT5A →	+0.404	+1.747	<.001	<.001	3	3
UCEC	STING1 →	-0.509	-1.525	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,577 associations by consensus.

GUF1 by DGKG expression — UCEC

Explore this box plot interactively →