DGKG

Across TCGA pan-cancer cohorts, DGKG RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of DGKG’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DGKG RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DGKG is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

HNSC, KICH, and KIRC are the cancer types where DGKG tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DGKG RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.143	<.001	12	view →
KICH	Male	II,III,IV	−0.875	<.001	11	view →
KIRC	All	II,III,IV	+0.417	<.001	10	view →
BLCA	Male	III,IV	−2.252	<.001	8	view →
THCA	All	All	−0.481	<.001	8	view →
UCEC	All	All	−0.677	.001	6	view →
BRCA	Female	II,III,IV	−0.140	<.001	6	view →
STAD	All	All	−0.994	.001	5	view →
LIHC	All	All	+0.251	.007	4	view →
LUAD	All	All	−0.254	.006	3	view →
CHOL	All	All	+1.032	<.001	2	view →
PRAD	All	All	−0.585	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

DGKG–HNSC

Open the HNSC breakdown →