DGKG

Across TCGA cell cohorts, DGKG mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DGKG-associated genes across cancer lineages are IL9, PAX1, and MMP27. Each is linked with DGKG in more than 1 cancer types. Because this analysis shows association rather than direction, both DGKG-to-partner and partner-to-DGKG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL9 grouped by DGKG-low versus DGKG-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DGKG→partner) and Y-score (partner→DGKG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	IL9 →	+0.097	+4.087	<.001	.009	3	2
BLOOD_Leukemia	PAX1 →	+0.029	+4.060	<.001	.003	3	2
PANCREAS	MMP27 →	+0.006	+5.614	<.001	.002	3	1
PANCREAS	TSPY4 →	+0.050	+5.614	<.001	.002	3	1
URINARY_TRACT	LYZL6 →	+0.113	+4.217	<.001	.005	3	1
LUNG_SCLC	FAM47B →	+0.016	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

IL9 by DGKG expression — URINARY_TRACT

Explore this box plot interactively →