Across TCGA patient cohorts, DENND6B mutation is significantly associated with the RNA expression of many other genes, with 756 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DENND6B-associated genes across cancer lineages are RNU7-195P, RN7SL794P, and CYP4F27P. Each is linked with DENND6B in more than 2 cancer types. Because this analysis shows association rather than direction, both DENND6B-to-partner and partner-to-DENND6B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND6B→partner) and Y-score (partner→DENND6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU7-195P →	+0.522	+4.145	.009	.002	3	3
SKCM	RN7SL794P →	+0.183	+2.894	<.001	.006	3	2
SKCM	CYP4F27P →	+0.305	+3.086	<.001	.004	3	2
UCEC	GPATCH11 →	+0.472	+3.491	.004	.002	3	2
UCEC	BUB3 →	+0.442	+2.807	.007	.003	3	2
UCEC	VPS26C →	+0.558	+3.600	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 756 associations by consensus.

Exploration

DENND6B survival (RNA) · tumor vs normal (RNA) · all DENND6B data types