DENND4C

Across TCGA patient cohorts, DENND4C RNA expression is significantly associated with the protein abundance of many other proteins, with 12,016 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible DENND4C-associated proteins across cancer lineages are DENND4C_S741, PSIP1, and CDC37L1. Each is linked with DENND4C in more than 6 cancer types. Because this analysis shows association rather than direction, both DENND4C-to-partner and partner-to-DENND4C results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DENND4C versus DENND4C_S741 in HNSC, with a Pearson correlation of 0.34.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND4C→partner) and Y-score (partner→DENND4C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DENND4C_S741 →	+0.553	+0.658	<.001	<.001	3	7
GBM	PSIP1 →	+0.464	+0.375	<.001	<.001	3	5
OV	CDC37L1 →	+0.318	+0.998	<.001	<.001	3	5
CCRCC	EEF2 →	-0.226	-0.369	<.001	<.001	3	5
GBM	DENND4C_S1126 →	+0.573	+0.493	<.001	<.001	3	5
BRCA	DENND4C_S1623 →	+1.333	+0.854	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,016 associations by consensus.

DENND4C vs DENND4C_S741 — HNSC

Explore this scatter interactively →