DENND4C

Across TCGA patient cohorts, DENND4C protein abundance is significantly associated with the RNA expression of many other genes, with 11,401 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DENND4C-associated genes across cancer lineages are ZDHHC21, RRAGA, and SMARCA2. Each is linked with DENND4C in more than 5 cancer types. Because this analysis shows association rather than direction, both DENND4C-to-partner and partner-to-DENND4C results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DENND4C versus ZDHHC21 in LSCC, with a Pearson correlation of 0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND4C→partner) and Y-score (partner→DENND4C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ZDHHC21 →	+0.763	+0.280	<.001	<.001	3	6
OV	RRAGA →	+0.517	+0.216	.001	.004	3	5
OV	SMARCA2 →	+0.698	+0.201	.004	.005	3	5
GBM	AK3 →	+0.595	+0.298	<.001	<.001	3	5
BRCA	PLPP6 →	+0.619	+0.224	<.001	<.001	3	5
LSCC	RIC1 →	+0.534	+0.236	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,401 associations by consensus.

DENND4C vs ZDHHC21 — LSCC

Explore this scatter interactively →