DENND4C

Across TCGA patient cohorts, DENND4C mutation is significantly associated with the RNA expression of many other genes, with 6,330 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DENND4C-associated genes across cancer lineages are PELO, MIS18A, and ZDHHC12. Each is linked with DENND4C in more than 2 cancer types. Because this analysis shows association rather than direction, both DENND4C-to-partner and partner-to-DENND4C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PELO grouped by DENND4C-low versus DENND4C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND4C→partner) and Y-score (partner→DENND4C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PELO →	+0.433	+1.389	<.001	<.001	3	3
UCEC	MIS18A →	+0.438	+1.807	<.001	<.001	3	3
UCEC	ZDHHC12 →	+0.293	+2.534	.002	<.001	3	3
UCEC	TTC9C →	+0.247	+1.667	<.001	<.001	3	3
UCEC	PSMD6 →	+0.344	+1.850	<.001	<.001	3	3
UCEC	APEH →	+0.364	+1.514	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,330 associations by consensus.

PELO by DENND4C expression — UCEC

Explore this box plot interactively →