DENND4C

Across TCGA patient cohorts, DENND4C mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DENND4C-associated genes across cancer lineages are ATM, 4E-BP1, and Di-Ras3. Each is linked with DENND4C in more than 2 cancer types. Because this analysis shows association rather than direction, both DENND4C-to-partner and partner-to-DENND4C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by DENND4C-low versus DENND4C-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND4C→partner) and Y-score (partner→DENND4C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	ATM →	-0.497	-3.169	.002	.017	3	3
COAD	4E-BP1 →	+0.283	+3.008	.012	.019	3	3
UCEC	Di-Ras3 →	-0.147	-2.649	<.001	<.001	3	3
BLCA	Mre11 →	-0.126	-2.309	.017	.033	3	2
BLCA	c-Kit →	-0.298	-2.459	.030	.018	3	2
COAD	Bad_pS112 →	-0.201	-2.991	.049	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

ATM by DENND4C expression — BLCA

Explore this box plot interactively →