DENND4C

Across TCGA cell cohorts, DENND4C RNA expression is significantly associated with the go_rna of many other GO terms, with 4,615 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DENND4C-associated GO terms across cancer lineages are Cilium or flagellum-dependent cell motility, Cilium-dependent cell motility, and Positive regulation of GTPase activity. Each is linked with DENND4C in more than 11 cancer types. Because this analysis shows association rather than direction, both DENND4C-to-partner and partner-to-DENND4C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cilium or flagellum-dependent cell motility grouped by DENND4C-low versus DENND4C-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND4C→partner) and Y-score (partner→DENND4C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Cilium or flagellum-dependent cell motility →	-0.137	-1.258	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Cilium-dependent cell motility →	-0.137	-1.258	<.001	<.001	3	12
SKIN	Positive regulation of GTPase activity →	+0.042	+0.760	<.001	.001	3	12
OVARY	Phosphatidylinositol-3-phosphate biosynthetic process →	+0.073	+0.960	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Cilium movement involved in cell motility →	-0.141	-1.145	<.001	<.001	3	11
BLOOD_Lymphoma	Golgi organization →	+0.065	+1.302	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,615 associations by consensus.

Cilium or flagellum-dependent cell motility by DENND4C expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →