DENND4A

Across TCGA patient cohorts, DENND4A mutation is significantly associated with the RNA expression of many other genes, with 4,110 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DENND4A-associated genes across cancer lineages are MED19, SLC30A2, and PTTG1. Each is linked with DENND4A in more than 3 cancer types. Because this analysis shows association rather than direction, both DENND4A-to-partner and partner-to-DENND4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MED19 grouped by DENND4A-low versus DENND4A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND4A→partner) and Y-score (partner→DENND4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MED19 →	+0.260	+1.364	.001	.008	3	3
UCEC	SLC30A2 →	-0.594	-1.111	.006	.005	3	3
UCEC	PTTG1 →	+0.401	+1.673	.009	.006	3	3
COAD	LEO1 →	+0.434	+3.209	.009	.009	3	3
UCEC	STIP1 →	+0.400	+1.807	<.001	<.001	3	3
UCEC	PDGFD →	-0.706	-1.357	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,110 associations by consensus.

MED19 by DENND4A expression — UCEC

Explore this box plot interactively →