DENND4A

Across TCGA pan-cancer cohorts, DENND4A RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of DENND4A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DENND4A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DENND4A is over-expressed in tumor, although a few such as UCEC and LUAD show the opposite, repressed pattern.

HNSC, UCEC, and LUAD are the cancer types where DENND4A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DENND4A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.686	<.001	11	view →
UCEC	All	All	−1.286	<.001	6	view →
LUAD	Female	II,III,IV	−0.743	<.001	6	view →
THCA	All	All	−0.313	.005	5	view →
CHOL	All	All	+1.245	.002	2	view →
READ	Female	All	−0.742	.008	2	view →
LUSC	All	III,IV	−0.663	.017	2	view →
STAD	Male	II,III,IV	+0.545	.021	2	view →
KICH	All	All	−0.534	.004	2	view →
PRAD	All	All	+0.238	.018	2	view →
KIRP	All	All	−0.250	.037	1	view →
KIRC	All	All	+0.214	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

DENND4A–HNSC

Open the HNSC breakdown →