DENND2C

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, DENND2C protein abundance is significantly associated with the RNA expression of many other genes, with 6,559 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible DENND2C-associated genes across cancer lineages are AMMECR1, KRT34, and FST. Each is linked with DENND2C in more than 1 cancer types. Because this analysis shows association rather than direction, both DENND2C-to-partner and partner-to-DENND2C results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DENND2C versus AMMECR1 in LSCC, with a Pearson correlation of 0.25.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND2C→partner) and Y-score (partner→DENND2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCAMMECR1 →+0.476+0.561.001<.00132
HNSCKRT34 →+1.059+0.367<.001<.00132
LSCCFST →+1.389+0.534.004.00832
HNSCDSC2 →+1.389+0.459<.001<.00132
LSCCDSG3 →+2.526+0.456<.001.00132
LSCCDSC3 →+1.891+0.461<.001.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 6,559 associations by consensus.

DENND2C vs AMMECR1 — LSCC

Per-sample scatter of DENND2C vs AMMECR1 in LSCC (Pearson r = 0.25).

Explore this scatter interactively →

Exploration