DENND2C

Across TCGA pan-cancer cohorts, DENND2C RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated DENND2C data layer compared with 11 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher DENND2C RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DENND2C expression acts as an unfavorable survival marker, although some lineages such as KIRC and UVM show a favorable association.

UCEC, KIRC, and UVM are the cancer types where DENND2C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.536	0.745	.002	82	view →
KIRC	OS	Median	All	0.855	0.757	<.001	76	view →
UVM	DFS	Tertile	II,III,IV	0.843	0.398	<.001	45	view →
LUSC	DFS	Tertile	II,III,IV	0.558	0.295	.001	37	view →
STAD	DFS	Quartile	All	0.429	0.621	.010	36	view →
KIRP	DFS	Tertile	III,IV	0.242	0.639	.014	32	view →
COAD	DFS	Median	All	0.592	0.763	.003	28	view →
PAAD	OS	Quartile	All	0.482	0.789	.002	24	view →
SKCM	DFS	Median	IV	0.763	0.187	.006	21	view →
LGG	OS	Quartile	All	0.339	0.719	<.001	21	view →
UCS	DFS	Median	II,III,IV	0.581	0.297	.019	20	view →
SCLC	OS	Median	II,III,IV	0.541	0.725	.029	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

DENND2C–UCEC (DFS)

Open the UCEC breakdown →