DENND2C

Across TCGA pan-cancer cohorts, DENND2C RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of DENND2C’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where DENND2C RNA is repressed in tumor relative to normal tissue. In most cancer types DENND2C is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and LUAD are the cancer types where DENND2C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DENND2C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	III,IV	−0.837	<.001	9	view →
THCA	Male	II,III,IV	−0.646	<.001	9	view →
LUAD	Female	III,IV	−0.734	<.001	7	view →
BRCA	All	III,IV	−0.903	<.001	6	view →
LUSC	Male	All	+1.082	<.001	4	view →
LIHC	Male	All	+0.685	<.001	4	view →
KIRC	All	All	+0.248	<.001	4	view →
CHOL	Female	All	−0.970	.007	2	view →
READ	Female	All	−0.608	.005	2	view →
PRAD	All	All	−0.437	<.001	2	view →
KIRP	Male	All	−0.257	.010	2	view →
COAD	All	All	−0.185	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

DENND2C–KICH

Open the KICH breakdown →