DENND2C

Across TCGA patient cohorts, DENND2C mutation is significantly associated with the RNA expression of many other genes, with 5,251 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DENND2C-associated genes across cancer lineages are ZWINT, LINC02380, and QPRT. Each is linked with DENND2C in more than 3 cancer types. Because this analysis shows association rather than direction, both DENND2C-to-partner and partner-to-DENND2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZWINT grouped by DENND2C-low versus DENND2C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND2C→partner) and Y-score (partner→DENND2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZWINT →	+0.766	+1.784	<.001	<.001	3	4
CESC	LINC02380 →	+0.103	+5.345	.003	.001	3	3
COAD	QPRT →	-1.299	-2.793	.005	.003	3	3
COAD	CENPM →	+0.815	+2.807	<.001	.003	3	3
UCEC	OIP5 →	+0.860	+2.523	<.001	<.001	3	3
UCEC	RPAIN →	+0.371	+2.123	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,251 associations by consensus.

ZWINT by DENND2C expression — UCEC

Explore this box plot interactively →