DENND2C

Across TCGA patient cohorts, DENND2C mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DENND2C-associated genes across cancer lineages are PKC-b-II_pS660, Stathmin, and Bad_pS112. Each is linked with DENND2C in more than 2 cancer types. Because this analysis shows association rather than direction, both DENND2C-to-partner and partner-to-DENND2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-b-II_pS660 grouped by DENND2C-low versus DENND2C-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND2C→partner) and Y-score (partner→DENND2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PKC-b-II_pS660 →	-0.331	-2.321	.026	.033	3	3
COAD	Stathmin →	+0.128	+3.012	.045	.018	3	3
COAD	Bad_pS112 →	-0.180	-2.576	.029	.011	3	3
UCEC	PDCD4 →	-0.581	-2.222	<.001	<.001	3	3
UCEC	PKC-delta_pS664 →	-0.082	-1.999	.025	.008	3	3
UCEC	Annexin-1 →	+0.520	+2.999	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

PKC-b-II_pS660 by DENND2C expression — COAD

Explore this box plot interactively →