DENND2C

Across TCGA cell cohorts, DENND2C RNA expression is significantly associated with the go_rna of many other GO terms, with 4,136 significant associations in total. BONE shows the largest number of these associations.

The most reproducible DENND2C-associated GO terms across cancer lineages are Positive regulation of ERAD pathway, Positive regulation of cytoplasmic translation, and Proteasomal ubiquitin-independent protein catabolic process. Each is linked with DENND2C in more than 11 cancer types. Because this analysis shows association rather than direction, both DENND2C-to-partner and partner-to-DENND2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of ERAD pathway grouped by DENND2C-low versus DENND2C-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND2C→partner) and Y-score (partner→DENND2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Positive regulation of ERAD pathway →	+0.082	+0.765	.001	<.001	3	12
STOMACH	Positive regulation of cytoplasmic translation →	+0.187	+1.408	<.001	<.001	3	10
OVARY	Proteasomal ubiquitin-independent protein catabolic process →	+0.088	+0.688	<.001	.003	2	11
STOMACH	Regulation of ubiquitin-dependent protein catabolic process →	+0.062	+1.082	<.001	<.001	3	10
STOMACH	Regulation of ERAD pathway →	+0.109	+1.044	<.001	<.001	3	9
STOMACH	Regulation of proteasomal protein catabolic process →	+0.080	+1.114	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,136 associations by consensus.

Positive regulation of ERAD pathway by DENND2C expression — STOMACH

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