DENND2C

Across TCGA cell cohorts, DENND2C mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible DENND2C-associated genes across cancer lineages are SPRR1A, DEFB126, and PRAMEF10. Each is linked with DENND2C in more than 1 cancer types. Because this analysis shows association rather than direction, both DENND2C-to-partner and partner-to-DENND2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPRR1A grouped by DENND2C-low versus DENND2C-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND2C→partner) and Y-score (partner→DENND2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SPRR1A →	+0.233	+4.930	.003	.008	3	2
CNS	DEFB126 →	+0.141	+4.472	<.001	.004	3	2
CNS	PRAMEF10 →	+0.276	+4.754	<.001	.005	3	2
SOFT_TISSUE	C20orf85 →	+0.115	+5.369	<.001	.004	3	1
SOFT_TISSUE	OR1L4 →	+0.072	+5.369	<.001	.004	3	1
SOFT_TISSUE	TBATA →	+0.013	+5.369	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

SPRR1A by DENND2C expression — SOFT_TISSUE

Explore this box plot interactively →