DENND1A

Across TCGA cell cohorts, DENND1A mutation is significantly associated with the RNA expression of many other genes, with 332 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DENND1A-associated genes across cancer lineages are SPACA5, TEX46, and OR10AG1. Each is linked with DENND1A in more than 1 cancer types. Because this analysis shows association rather than direction, both DENND1A-to-partner and partner-to-DENND1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPACA5 grouped by DENND1A-low versus DENND1A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND1A→partner) and Y-score (partner→DENND1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SPACA5 →	+0.060	+2.041	<.001	.007	3	2
BLOOD_Leukemia	TEX46 →	+0.180	+3.803	<.001	.004	3	2
LUNG_NSCLC_LUAD	OR10AG1 →	+0.032	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR2AJ1 →	+0.024	+4.734	<.001	.002	3	1
LUNG_NSCLC_LUAD	KCNK18 →	+0.014	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	GLT6D1 →	+0.004	+4.662	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 332 associations by consensus.

SPACA5 by DENND1A expression — LARGE_INTESTINE

Explore this box plot interactively →