DENND1A

Across TCGA pan-cancer cohorts, DENND1A RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of DENND1A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DENND1A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DENND1A is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

HNSC, LUAD, and LIHC are the cancer types where DENND1A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DENND1A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.922	<.001	11	view →
LUAD	Male	III,IV	+1.083	<.001	7	view →
LIHC	Female	II,III,IV	+0.696	<.001	7	view →
LUSC	All	II,III,IV	+0.688	<.001	7	view →
STAD	All	II,III,IV	+0.682	.001	6	view →
KICH	All	All	−0.568	<.001	6	view →
BRCA	All	II,III,IV	+0.198	<.001	6	view →
CHOL	All	All	+0.945	.001	5	view →
BLCA	Male	IV	−1.047	.002	2	view →
ESCA	All	All	+0.912	.002	2	view →
UCEC	All	All	−0.548	.003	2	view →
PRAD	All	All	+0.418	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

DENND1A–HNSC

Open the HNSC breakdown →