DEFB4B

Across TCGA cell cohorts, DEFB4B RNA expression is significantly associated with the mutation status of many other genes, with 53 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible DEFB4B-associated genes across cancer lineages are CACNA1S, TRPC7, and HELZ2. Each is linked with DEFB4B in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFB4B-to-partner and partner-to-DEFB4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CACNA1S grouped by DEFB4B-low versus DEFB4B-high in SOFT_TISSUE.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB4B→partner) and Y-score (partner→DEFB4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CACNA1S →	+4.392	+0.072	.004	<.001	3	2
BLOOD_Leukemia	TRPC7 →	+5.539	+0.313	.003	<.001	3	2
OESOPHAGUS	HELZ2 →	+2.857	+0.114	.007	<.001	3	1
OESOPHAGUS	CNTNAP5 →	+3.273	+0.133	.004	<.001	3	1
OESOPHAGUS	ZNF518B →	+4.857	+0.200	<.001	<.001	3	1
SOFT_TISSUE	ASAH1 →	+5.977	+0.120	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

CACNA1S by DEFB4B expression — SOFT_TISSUE

Explore this box plot interactively →