DEFB4B

Across TCGA pan-cancer cohorts, DEFB4B RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of DEFB4B’s most consistent transcriptional readouts.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where DEFB4B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DEFB4B is over-expressed in tumor.

UCEC and LUAD are the cancer types where DEFB4B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DEFB4B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
UCEC	All	All	+0.263	.033	2	view →
LUAD	All	All	+0.137	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

DEFB4B–UCEC

Open the UCEC breakdown →