DEFB4B

Across TCGA pan-cancer cohorts, DEFB4B RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated DEFB4B data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher DEFB4B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DEFB4B expression acts as an unfavorable survival marker, although some lineages such as ESCA and PAAD show a favorable association.

UCS, STAD, and KIRC are the cancer types where DEFB4B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Tertile	All	0.102	0.688	<.001	108	view →
STAD	DFS	Tertile	All	0.481	0.674	<.001	75	view →
KIRC	DFS	Tertile	III,IV	0.204	0.747	<.001	72	view →
THYM	OS	Tertile	All	0.569	0.928	.002	63	view →
LUSC	OS	Tertile	IV	0.001	0.673	.014	54	view →
SKCM	OS	Tertile	All	0.486	0.794	<.001	48	view →
SCLC	OS	Tertile	II,III,IV	0.361	0.917	.002	21	view →
LUAD	DFS	Tertile	IV	0.047	0.565	<.001	18	view →
OV	DFS	Tertile	IV	0.317	0.506	.029	18	view →
ESCA	OS	Median	IV	0.698	0.222	.006	12	view →
PAAD	DFS	Tertile	II,III,IV	0.609	0.267	.032	9	view →
BLCA	DFS	Tertile	III,IV	0.331	0.579	.041	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

DEFB4B–UCS (OS)

Open the UCS breakdown →