DEFB4A

Across TCGA cell cohorts, DEFB4A RNA expression is significantly associated with the go_rna of many other GO terms, with 399 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible DEFB4A-associated GO terms across cancer lineages are Positive regulation of reactive oxygen species biosynthetic process, Regulation of leukocyte migration, and Cellular response to molecule of bacterial origin. Each is linked with DEFB4A in more than 3 cancer types. Because this analysis shows association rather than direction, both DEFB4A-to-partner and partner-to-DEFB4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of reactive oxygen species biosynthetic process grouped by DEFB4A-low versus DEFB4A-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB4A→partner) and Y-score (partner→DEFB4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Positive regulation of reactive oxygen species biosynthetic process →	+0.141	+1.445	<.001	.007	3	4
UPPER_AERODIGESTIVE_TRACT	Regulation of leukocyte migration →	+0.071	+1.594	.002	.004	3	4
UPPER_AERODIGESTIVE_TRACT	Cellular response to molecule of bacterial origin →	+0.086	+1.687	<.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	Cellular response to lipopolysaccharide →	+0.091	+1.687	<.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	Cellular response to tumor necrosis factor →	+0.094	+1.740	<.001	.002	3	4
LUNG_NSCLC_LUAD	Regulation of toll-like receptor 2 signaling pathway →	+0.079	+0.313	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 399 associations by consensus.

Positive regulation of reactive oxygen species biosynthetic process by DEFB4A expression — OVARY

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