DEFB4A

Across TCGA pan-cancer cohorts, DEFB4A RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of DEFB4A’s most consistent transcriptional readouts.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where DEFB4A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DEFB4A is over-expressed in tumor.

UCEC, LUAD, and LUSC are the cancer types where DEFB4A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DEFB4A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
UCEC	All	All	+1.270	.001	6	view →
LUAD	Female	All	+1.119	<.001	5	view →
LUSC	Male	All	+0.879	.004	2	view →
COAD	Female	II,III,IV	+0.424	.032	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

DEFB4A–UCEC

Open the UCEC breakdown →