DEFB4A

Across TCGA pan-cancer cohorts, DEFB4A RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated DEFB4A data layer.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher DEFB4A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DEFB4A expression acts as an unfavorable survival marker, although some lineages such as CHOL and ESCA show a favorable association.

STAD, SKCM, and LIHC are the cancer types where DEFB4A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	DFS	Tertile	II,III,IV	0.512	0.692	.004	44	view →
SKCM	OS	Tertile	All	0.648	0.822	.001	28	view →
LIHC	DFS	Tertile	II,III,IV	0.125	0.476	.006	24	view →
SCLC	OS	Median	II,III,IV	0.421	1.000	.002	22	view →
BLCA	DFS	Tertile	IV	0.309	0.496	.012	21	view →
THCA	DFS	Tertile	IV	0.075	0.807	<.001	21	view →
UCS	OS	Tertile	II,III,IV	0.385	0.656	.045	18	view →
GBM	OS	Tertile	All	0.234	0.422	.017	18	view →
KIRC	DFS	Tertile	All	0.729	0.866	.020	18	view →
CHOL	DFS	Tertile	II,III,IV	1.000	0.196	.016	18	view →
OV	DFS	Tertile	IV	0.320	0.586	.015	12	view →
ESCA	OS	Median	IV	0.698	0.222	.006	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

DEFB4A–STAD (DFS)

Open the STAD breakdown →