Across TCGA patient cohorts, DEFB133 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DEFB133-associated genes across cancer lineages are RNU6-1082P, C7orf66, and RNU6-541P. Each is linked with DEFB133 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFB133-to-partner and partner-to-DEFB133 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB133→partner) and Y-score (partner→DEFB133) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-1082P →	+0.804	+6.136	<.001	<.001	3	1
UCEC	C7orf66 →	+0.394	+4.256	.006	.008	3	1
UCEC	RNU6-541P →	+0.696	+5.223	<.001	.001	3	1
UCEC	RNU6-628P →	+1.023	+4.473	<.001	.005	3	1
UCEC	PPIAP17 →	+0.212	+4.748	.007	.003	3	1
UCEC	MARK2P5 →	+0.107	+4.694	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

DEFB133 survival (RNA) · tumor vs normal (RNA) · all DEFB133 data types