DEFB130B

Across TCGA patient cohorts, DEFB130B RNA expression is significantly associated with the mutation status of many other genes, with 31 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible DEFB130B-associated genes across cancer lineages are SYF2, TRERF1, and NEK3. Each is linked with DEFB130B in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFB130B-to-partner and partner-to-DEFB130B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SYF2 grouped by DEFB130B-low versus DEFB130B-high in KIRC.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB130B→partner) and Y-score (partner→DEFB130B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRC	SYF2 →	+8.025	+0.154	.007	<.001	3	1
KIRC	TRERF1 →	+8.025	+0.154	.007	<.001	3	1
KIRC	NEK3 →	+8.025	+0.154	.007	<.001	3	1
KIRC	RABGGTB →	+8.025	+0.154	.007	<.001	3	1
KIRC	ABI2 →	+8.025	+0.154	.007	<.001	3	1
KIRC	MCPH1 →	+8.025	+0.154	.007	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

SYF2 by DEFB130B expression — KIRC

Explore this box plot interactively →