DEFB126

Across TCGA patient cohorts, DEFB126 mutation is significantly associated with the RNA expression of many other genes, with 92 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible DEFB126-associated genes across cancer lineages are DNM1P28, CTBP2P9, and OR4K17. Each is linked with DEFB126 in more than 2 cancer types. Because this analysis shows association rather than direction, both DEFB126-to-partner and partner-to-DEFB126 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNM1P28 grouped by DEFB126-low versus DEFB126-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB126→partner) and Y-score (partner→DEFB126) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DNM1P28 →	+0.122	+5.099	<.001	.008	3	3
LUSC	CTBP2P9 →	+0.032	+4.882	<.001	.005	3	3
LUAD	OR4K17 →	+0.085	+7.108	<.001	<.001	3	2
LUAD	RNA5SP327 →	+0.329	+6.087	<.001	.002	3	2
LUSC	BCAS2P3 →	+0.049	+4.625	.009	.008	3	2
UCEC	MTATP6P21 →	+0.502	+4.552	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 92 associations by consensus.

DNM1P28 by DEFB126 expression — LUAD

Explore this box plot interactively →