DEFB126

Across TCGA pan-cancer cohorts, DEFB126 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of DEFB126’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where DEFB126 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DEFB126 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.

LUSC, BLCA, and HNSC are the cancer types where DEFB126 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DEFB126 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	II,III,IV	+1.734	<.001	6	view →
BLCA	All	All	+0.830	.001	6	view →
HNSC	Male	All	+0.345	.002	5	view →
UCEC	All	All	+0.543	.006	4	view →
BRCA	Female	All	+0.099	.015	4	view →
KIRC	All	All	−0.016	.002	4	view →
ESCA	All	II,III,IV	+0.665	.009	2	view →
STAD	All	All	+0.209	.028	2	view →
LUAD	All	All	+0.166	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

DEFB126–LUSC

Open the LUSC breakdown →