DEFB124

Across TCGA patient cohorts, DEFB124 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. COAD shows the largest number of these associations.

The most reproducible DEFB124-associated genes across cancer lineages are RNU6-110P, RNU6-1274P, and TRAJ54. Each is linked with DEFB124 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFB124-to-partner and partner-to-DEFB124 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-110P grouped by DEFB124-low versus DEFB124-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB124→partner) and Y-score (partner→DEFB124) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-110P →	+0.561	+4.181	<.001	.009	3	1
COAD	RNU6-1274P →	+0.298	+5.122	.007	.004	3	1
COAD	TRAJ54 →	+0.951	+5.173	<.001	.001	3	1
COAD	TRAJ19 →	+0.928	+5.173	<.001	.001	3	1
COAD	RNU6-932P →	+0.306	+4.790	<.001	.006	3	1
COAD	RNU6-628P →	+0.572	+4.792	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

RNU6-110P by DEFB124 expression — COAD

Explore this box plot interactively →