Across TCGA patient cohorts, DEFB110 mutation is significantly associated with the RNA expression of many other genes, with 73 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible DEFB110-associated genes across cancer lineages are MIR3651, RNA5SP430, and BNIP3P6. Each is linked with DEFB110 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFB110-to-partner and partner-to-DEFB110 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB110→partner) and Y-score (partner→DEFB110) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR3651 →	+0.309	+2.237	.008	.005	3	2
LUSC	RNA5SP430 →	+0.288	+4.297	<.001	.009	3	2
LUSC	BNIP3P6 →	+0.174	+4.496	<.001	.007	3	2
SKCM	AK4P6 →	+0.048	+2.809	<.001	.004	3	1
SKCM	LINC02066 →	+0.949	+2.263	<.001	.004	3	1
SKCM	PPP1R2P6 →	+0.117	+2.578	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

Exploration

DEFB110 survival (RNA) · tumor vs normal (RNA) · all DEFB110 data types