DEFA4

Across TCGA patient cohorts, DEFA4 mutation is significantly associated with the RNA expression of many other genes, with 348 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible DEFA4-associated genes across cancer lineages are LINC00973, ZNF877P, and SIGLEC27P. Each is linked with DEFA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFA4-to-partner and partner-to-DEFA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC00973 grouped by DEFA4-low versus DEFA4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFA4→partner) and Y-score (partner→DEFA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	LINC00973 →	+1.051	+2.738	<.001	.003	3	2
COAD	ZNF877P →	+0.095	+5.693	.005	.003	3	2
LUAD	SIGLEC27P →	+0.062	+7.333	<.001	<.001	3	2
SKCM	RNU4-58P →	+0.128	+3.163	<.001	.001	3	2
SKCM	SIN3B →	+0.450	+2.497	<.001	.009	3	2
SKCM	MIR548AW →	+0.114	+3.302	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 348 associations by consensus.

LINC00973 by DEFA4 expression — SKCM

Explore this box plot interactively →