DEFA3

Across TCGA patient cohorts, DEFA3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,674 significant associations in total. THYM shows the largest number of these associations.

The most reproducible DEFA3-associated GO terms across cancer lineages are Disruption of plasma membrane integrity in another organism, Leukocyte aggregation, and Nitric oxide transport. Each is linked with DEFA3 in more than 21 cancer types. Because this analysis shows association rather than direction, both DEFA3-to-partner and partner-to-DEFA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Disruption of plasma membrane integrity in another organism grouped by DEFA3-low versus DEFA3-high in LAML.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFA3→partner) and Y-score (partner→DEFA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	Disruption of plasma membrane integrity in another organism →	+1.450	+2.517	<.001	<.001	3	22
LAML	Leukocyte aggregation →	+0.105	+1.547	<.001	.002	2	16
PAAD	Nitric oxide transport →	+0.076	+0.151	<.001	.002	3	13
LAML	Neutrophil chemotaxis →	+0.047	+1.198	<.001	<.001	3	11
LAML	Autocrine signaling →	+0.117	+1.586	<.001	<.001	3	11
LAML	Disruption of cellular anatomical structure in another organism →	+1.569	+2.403	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,674 associations by consensus.

Disruption of plasma membrane integrity in another organism by DEFA3 expression — LAML

Explore this box plot interactively →