DEFA3

Across TCGA cell cohorts, DEFA3 RNA expression is significantly associated with the mutation status of many other genes, with 136 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DEFA3-associated genes across cancer lineages are FAM189B, ZSCAN5A, and AADACL4. Each is linked with DEFA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFA3-to-partner and partner-to-DEFA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM189B grouped by DEFA3-low versus DEFA3-high in SOFT_TISSUE.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFA3→partner) and Y-score (partner→DEFA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	FAM189B →	+4.515	+0.123	<.001	<.001	3	2
BLOOD_Lymphoma	ZSCAN5A →	+4.867	+0.733	.009	<.001	3	2
BLOOD_Lymphoma	AADACL4 →	+4.867	+0.886	.009	<.001	3	2
CNS	ABLIM3 →	+4.772	+0.040	.002	<.001	3	2
BLOOD_Leukemia	MT-CYB →	+2.703	+2.241	.002	<.001	3	2
LUNG_NSCLC_LUAD	CFAP100 →	+3.887	+0.101	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 136 associations by consensus.

FAM189B by DEFA3 expression — SOFT_TISSUE

Explore this box plot interactively →