Q-omics provides the consensus-scored DEFA11P profile across patient tissues and cancer cell-line models. DEFA11P expression is associated with patient survival in 11 of 34 cancer types, with the highest sampling consensus in HNSC. Additionally, DEFA11P RNA expression shows 4,999 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight HNSC, and THYM as cancer lineages where DEFA11P shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.

Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.

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Survival associations

This table summarizes DEFA11P survival associations across molecular data types. DEFA11P RNA expression shows survival associations in the most cancer types (11). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.

DEFA11P data type	Survival analysis	Lineage consensus	Lineage of highest sampling consensus
RNA	Kaplan–Meier	11	HNSC (60)	view →

This table ranks reproducible DEFA11P RNA expression–survival associations across cancer types. High DEFA11P expression shows unfavorable associations in HNSC, LUAD, KIRP, LUSC and ACC, but favorable associations in THYM. The HNSC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .005). Together, the overview and detailed table identify HNSC as the clearest survival context for DEFA11P RNA expression.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	II,III,IV	0.397	0.690	.005	60	view →
LUAD	OS	Tertile	III,IV	0.226	0.687	<.001	54	view →
KIRP	DFS	Tertile	II,III,IV	0.174	0.701	.001	39	view →
LUSC	OS	Tertile	All	0.312	0.731	.013	27	view →
ACC	DFS	Tertile	II,III,IV	0.242	0.724	.034	18	view →
THYM	OS	Tertile	All	0.956	0.623	.038	12	view →

Pink = unfavorable, green = favorable. all 11 lineages →

DEFA11P-HNSC (DFS)

Kaplan–Meier survival curve for DEFA11P RNA expression in HNSC: high vs low expression groups.

Explore this curve interactively →

Cross-omics associations

This table shows molecular features associated with DEFA11P in patient tissues and cancer cell lines. In patient samples, DEFA11P shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set.

Associated data type	Strength (# associated data)	Lineage of highest associated data
▼RNA
RNA	4,999	THYM (1995)	view →
Function (RNA)	4,866	STAD (4004)	view →