DEFA11P

Across TCGA pan-cancer cohorts, DEFA11P RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated DEFA11P data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DEFA11P RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DEFA11P expression acts as an unfavorable survival marker, although some lineages such as THYM and COAD show a favorable association.

HNSC, LUAD, and KIRP are the cancer types where DEFA11P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	II,III,IV	0.397	0.690	.005	60	view →
LUAD	OS	Tertile	III,IV	0.226	0.687	<.001	54	view →
KIRP	DFS	Tertile	II,III,IV	0.174	0.701	.001	39	view →
LUSC	OS	Tertile	All	0.312	0.731	.013	27	view →
ACC	DFS	Tertile	II,III,IV	0.242	0.724	.034	18	view →
THYM	OS	Tertile	All	0.956	0.623	.038	12	view →
KICH	DFS	Tertile	All	0.657	0.911	.039	9	view →
READ	DFS	Tertile	IV	0.255	0.628	.020	9	view →
LIHC	DFS	Tertile	All	0.151	0.555	.047	9	view →
COAD	OS	Tertile	All	1.000	0.592	.037	6	view →
UCEC	OS	Tertile	All	0.813	0.927	.049	6	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

DEFA11P–HNSC (DFS)

Open the HNSC breakdown →