DEF8

Across TCGA patient cohorts, DEF8 mutation is significantly associated with the RNA expression of many other genes, with 2,842 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DEF8-associated genes across cancer lineages are DUXAP3, UBE2D3P4, and USP9YP10. Each is linked with DEF8 in more than 2 cancer types. Because this analysis shows association rather than direction, both DEF8-to-partner and partner-to-DEF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DUXAP3 grouped by DEF8-low versus DEF8-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEF8→partner) and Y-score (partner→DEF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DUXAP3 →	+0.118	+4.398	.002	.006	3	3
BLCA	UBE2D3P4 →	+0.042	+6.055	<.001	<.001	3	3
LGG	USP9YP10 →	+0.049	+7.977	<.001	.007	3	2
HNSC	RPL39P25 →	+0.391	+4.425	<.001	.006	3	2
STAD	MIR542 →	+0.427	+3.981	<.001	.005	3	2
SKCM	MRPS22P1 →	+0.029	+4.049	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,842 associations by consensus.

DUXAP3 by DEF8 expression — HNSC

Explore this box plot interactively →