DDX46

Across TCGA cell cohorts, DDX46 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible DDX46-associated genes across cancer lineages are ART1, MPC1L, and SSX7. Each is linked with DDX46 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX46-to-partner and partner-to-DDX46 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ART1 grouped by DDX46-low versus DDX46-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX46→partner) and Y-score (partner→DDX46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ART1 →	+0.035	+4.011	<.001	.009	3	1
BLOOD_Leukemia	MPC1L →	+0.077	+4.409	<.001	.005	3	1
STOMACH	SSX7 →	+0.325	+4.285	<.001	.007	3	1
SKIN	HDGFL1 →	+0.241	+4.273	<.001	.006	3	1
SKIN	LCN1 →	+0.346	+4.095	<.001	.009	3	1
SKIN	KRTAP9-1 →	+0.035	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

ART1 by DDX46 expression — PANCREAS

Explore this box plot interactively →